Clearsynth Discovery | Integrated Drug Discovery Services

Integrated Drug Discovery Services

Clearsynth is a Contract Research Organization providing services like Preclinical drug discovery (from conceptualization to pre clinical POC) using different Artificial Intelligence and Machine learning (AI/ML) tools. The R&D team is capable of working on diverse projects starting from identifying key therapeutic areas, Identification of HIT, Optimization from HIT to lead and in Vivo POC establish in animal disease model.

Computational drug discovery plays a vital role by providing powerful tools and methods to understand, model, and optimize the interactions between drugs and biological targets. It involves the use of computational techniques to simulate and predict the behavior of molecules, which can significantly accelerate the drug discovery process.

Target ID & validation
Virtual screening
Fragment based hit identification
Molecular docking
Denovo ligand design

Scaffold hopping
QSAR studies
e-ADME analysis
Isostere predictions
ADMET modeling

Medicinal & synthetic chemistry:

The goal is to discover and develop new therapeutic agents that are effective, safe, and selective in treating or preventing diseases. Clearsynth has an expertise in the following services:

Designing of the compound for the desired therapeutic target using computational approach.
Hit identification, hit to lead optimization and development of clinical candidate nomination.
Structure Activity Relationship (SAR) generation.
Route scouting, combinatorial library design and synthesis
Designing of covalent inhibitors and libraries
Expertise in the synthesis of chiral compounds, metabolites, Isotope label compounds and impurities synthesis.

Analytical Chemistry:

Analytical chemistry involves different techniques such as infrared (IR), nuclear magnetic resonance (NMR), and mass spectrometry to identify functional groups and molecular structures. providing essential information for quality control, research, environmental monitoring, and many other fields. Advances in instrumentation, automation, and data analysis continue to enhance the capabilities and efficiency of analytical techniques.

List of Equipment

Name of Instruments	Instrument brand	Number of instruments
600 MHz Bio NMR	Bruker	1
ICP MS	Perkin Elmer	1
GC-HS/MS	Thermo	1
LCMS	AB Sciex and Shimadzu	2
TGA	Perkin Elmer	1
Prep HPLC	Shimadzu	2
HPLC	Waters	3
	Dionex	1
	Thermo	6
Flash System	SapaBean	1
Coulometer	Metrohm	1
IR	Shimadzu	1

It involves a series of studies and experiments conducted in the laboratory and in animal models to assess the safety, pharmacokinetics, and efficacy of a potential drug candidate before advancing to human clinical trials. The primary goals of preclinical development are to gather sufficient data to support the Investigational New Drug (IND) application to regulatory authorities and to identify potential risks and benefits associated with the drug candidate.

Cell-free and cell-based assay
In vitro and In vivo assay
In vivo animal model
In vitro ADME
In Vivo Toxicology (GLP and Non-GLP)

Physiochemical and DMPK:

DMPK is crucial in optimizing drug candidates for safety, efficacy, and regulatory compliance during the drug development process. Clearsynth collaborates with pharmaceutical and biotechnology companies to enhance the success of their drug development programs.

Physicochemical analysis
Permeability assay
Metabolism assay
Distribution and Excretion
Pharmacokinetics

Integrated Drug Discovery

Integrated Drug Discovery Services

Computational drug discovery

Target ID & validation

Virtual screening

Fragment based hit identification

Molecular docking

Denovo ligand design

Scaffold hopping

QSAR studies

e-ADME analysis

Isostere predictions

ADMET modeling

Chemistry services

Medicinal & synthetic chemistry:

Designing of the compound for the desired therapeutic target using computational approach.

Hit identification, hit to lead optimization and development of clinical candidate nomination.

Structure Activity Relationship (SAR) generation.

Route scouting, combinatorial library design and synthesis

Designing of covalent inhibitors and libraries

Expertise in the synthesis of chiral compounds, metabolites, Isotope label compounds and impurities synthesis.

Analytical Chemistry:

List of Equipment

Pre-clinical Biology:

Cell-free and cell-based assay

In vitro and In vivo assay

In vivo animal model

In vitro ADME

In Vivo Toxicology (GLP and Non-GLP)

Physiochemical and DMPK:

Physicochemical analysis

Permeability assay

Metabolism assay

Distribution and Excretion

Pharmacokinetics